In a medium bowl, combine the cream cheese, shredded cheddar, diced jalapeños, garlic powder, and onion powder until well mixed.
Lay an egg roll wrapper on a clean, flat surface, with a corner facing you.
Place 2 tablespoons of the jalapeño mixture about 2 inches from the corner.
Fold the bottom corner over the filling, then fold in the side corners, and roll tightly.
Seal the edge with a bit of water, pressing to ensure it stays closed during frying.
Heat vegetable oil in a large pot or deep skillet over medium-high heat until shimmering.
Fry the egg rolls in batches until golden brown, about 4-5 minutes per side.
Remove from oil and drain on paper towels before serving.