Preheat your oven to 375°F (190°C).
In a large mixing bowl, combine the cream of chicken soup, sour cream, garlic powder, onion powder, salt, and pepper.
Place the chicken breasts in a greased 9x13-inch baking dish, and pour the cream mixture over the top, ensuring the chicken is well covered.
Sprinkle the shredded cheddar cheese evenly over the top of the chicken and sauce mixture.
Finish by sprinkling the crushed buttery crackers evenly over the cheese layer.
Bake in the preheated oven for 30-40 minutes, or until the chickens are cooked through and the top is golden brown.
Let the dish rest for a few minutes before serving to allow the sauce to settle.